Lourdes J. Cruz: Journey to National Scientist

March 23, 2025 11:57 AM PHT

Glaiza Alvarez

 

Neuroscience has long been a highly important field of science, leading to numerous breakthroughs in practical treatments for neurological diseases. One of its most unexpected breakthroughs came from an unlikely source—conotoxins from sea snails—a discovery made by Filipina scientist Lourdes J. Cruz. Her research not only demonstrated Filipino scientists’ global impact but also intensified science’s role in serving her fellow countrymen.

Serving as an inspiration to many Filipino scientists and young women, Cruz, whose full name is Lourdes Jansuy Cruz, was born in the Philippines on May 19, 1942, to her father, Ramon Arao Cruz, and her mother, Julita Tolentino Jansuy. Her father was a chemist at the University of Philippines Los Baños (UPLB), while her mother was a former dentist. 

Cruz accumulated an impressive educational background, earning her Bachelor of Science in Chemistry in 1962 at the University of the Philippines Diliman (UPD). Later, she studied and graduated with a Master of Science and a PhD in Biochemistry at the University of Iowa, both in 1966 and 1968, respectively, in the United States. As an avid researcher, she has published and collaborated in making more than a hundred research papers, publishing 120 in ResearchGate and more than 200 in Google Scholar.

Currently, 44 distinguished scientists have been conferred the title of National Scientist in the Philippines since the creation of the National Academy of Science and Technology (NAST) on the 16th of December 1976, under Presidential Decree No. 1003-A. The Order of National Scientist Award is the highest honor given to a Filipino man or woman by the President after a respected collaborative or individual achievement in science and/or technology. Cruz is one of the most notable scientists honored to be granted this title for her significant contributions to the documentation of marine animal toxins, enhancing society’s understanding of the human brain’s functionality. Her work has led to numerous scientific advancements that improve human lives, aligning with the Sustainable Development Goals (SDGs), including SDG 1 (Zero Poverty), SDG 3 (Good Health and Well-being), and SDG 14 (Life Below Water).

Making waves

Cruz’s studies contributed to the biochemical characterization of more than 50 biologically active peptides from the Conus Venom. Peptides are short strings of two or more amino acids formed by a condensation reaction and joined together through a covalent bond, essential in numerous fundamental biochemical and physiological processes. Among her most notable works, alongside her fellow researcher Baldomero “Toto” Olivera, most notable work is her research on the Conus species, a genus of sea snails, with their discovery regarding venoms they produce called conotoxins, specifically the w-conotoxin and the m-conotoxin.

In relation to SDG 14, they studied the species of Conus geographus, a venomous cone snail found in the Philippines, known for causing illnesses and death. Supporting SDG 3, her team made critical discoveries and advancements in neuroscience by studying the effects of venom on the nervous system. Now, w-conotoxin is widely used in studying neuronal calcium channels, while m-conotoxin is used to prohibit muscular movement when investigating actions at the synapse. Their research also aided in the development of therapeutic drugs. 

Transforming lives

In 2001, as president of the Bataan Center for Innovative Science and Technology (BCISTI), Cruz founded the Rural Livelihood Incubator (Rural LINC), an organization dedicated to creating jobs and sustainable livelihoods for people in poverty—particularly women—in Bataan, aligning with SDG 1. At first, the organization began its operations in Morong, Bataan, where they sought to give jobs to the poorest residents of the region—the Pasama-Anahao farmers, the fishermen, and the Aetas, who live in Kanawan. Faced with many difficulties—such as the lack of education and understanding of the people—Rural LINC persevered. Like its founder, the organization found solutions, such as hiring volunteers to help teach the locals. 

Aside from being named a member of the Order of National Scientists by former president Gloria Macapagal-Arroyo, Cruz was also awarded the Outstanding Young Scientist Award by the  National Academy of Science and Technology (NAST) in 1981, the Achievement Award in Chemistry by the National Research Council of the Philippines (NRCP) in 1982, and the Outstanding Women in the Nation’s Service Award (Biochemistry) in 1986. Other than that, her awards include the Sven Brohult Award in 1993, the ASEAN Outstanding Scientist and Technologist Award in 2001, and the L’Oréal-UNESCO For Women in Science Award in 2010. Furthermore, Cruz and Olivera’s research on the Conus genus and their conotoxins recently obtained the Golden Goose Award in 2022.

In the Science, Technology, Engineering, and Mathematics (STEM) strand, Cruz’s success and achievements depicted the importance of science and technology to the progress of society. Through her research, she contributed to finding ways to help people alleviate neurological conditions, which are often complicated, deadly, and incurable. Despite the inferiority that Filipino women still face, having a Filipina conferred as one of the few National Scientists who is recognized not only nationally but also internationally sparks confidence and inspiration among young Filipinas who also plan to venture into her field, igniting a burning hope that success could be within reach through faith and determination.

Values in action

In a world filled with hate, compassion is now more important than ever. When Cruz worked with the Aetas in her LINC program, she never forced them to do anything against their will. Instead, she showed them respect by respecting their boundaries and letting them make their own decisions. Despite the incidents of Aeta children being called “buklaw” by their teachers and their frequent absences, Cruz helped them foster a mutual appreciation for each other, developing friendships that expand beyond cultural differences. She served as a gentle, guided hand to the often misunderstood Aetas

Furthermore, Cruz incorporates the value of charity by assisting the Aetas in finding livelihood opportunities. Not only did she provide education to the Aetas and make them more fond of education, but she also facilitated alternative and sustainable sources of livelihood outside of farming, such as beekeeping, ecotourism, and the use of green charcoal, permaculture, and agroforestry. With the help of Cruz, Grace Yu, and the organization, they were able to conduct research on the medicinal properties of limuran—an Aeta dish made of a unique type of rattan. They figured out that the dish contained anti-inflammatory and anti-cancer compounds, which opened up possibilities for commercializing Aeta’s traditional medicine while generating more money for the locals. 

Embodying the value of service, Cruz’s work has shown that she has a heart of gold. Through her research involving the poisonous peptides found in the venom of cone snails (Conus), seven Conus venom-based therapeutic products for pain, epilepsy, and heart attacks (myocardial infarction) reached Phase 1 in 2006. Her research has paved the way for future scientists to develop better medical treatments for people with chronic diseases. It has significantly eased many people who have chronic pain, showing that her tireless efforts were not in vain. 

Through her valuable contribution to research, Cruz has proven she is worthy to be among the 44 members of the Order of National Scientists in the Philippines. Her works, along with those of her fellow National Scientists, emphasized the importance of the development of science in our country and its functionality and usefulness to society. 

Despite the country’s problems and status as a developing country, the achievements of the Order of National Scientists highlighted the country’s ability to contribute to the world of science, technology, and innovation. More than just a scientist, Cruz is an inspirational figure who shows compassion to those around her—living the motto that nothing is truly impossible. 

 
 

Scientia. (2018, August 1). DR. LOURDES JANSUY CRUZ: SCIENTIST TO THE BARRIOS. Issuu. https://issuu.com/upscientia/docs/scientia_vol._25_issue_no.2/s/10904674

FlipScience. (2019, June 26). Dr. Lourdes J. Cruz: The Pinay biochemist who studied a deadly snail – FlipScience – Top Philippine science news and features for the inquisitive Filipino. FlipScience – Top Philippine Science News and Features for the Inquisitive Filipino. https://www.flipscience.ph/features/national-scientist-lourdes-j-cruz/

Forbes, J. & Krishnamurthy, K. (2023, Aug 28). Biochemistry, Peptide. StatPearls [Internet]. National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK562260/

National Academy of Science and Technology. (n.d.). List of National scientist. https://www.members.nast.ph/index.php/list-of-national-scientist/details/3/12#educational-background

NAST Philippines. (2025). NAST recognition. NAST Recognition Function. https://recognition.nast.ph/

Rodil, N. M. (2024, August 8). Malacañang conferred the 44th National Scientist of the Philippine. National Academy of Science and Technology. https://nast.dost.gov.ph/index.php/13-news-press-releases/789-malacanang-conferred-the-44th-national-scientist-of-the-philippine

Department of Science and Technology. (n.d.). Lourdes J. Cruz. Government of the Philippines. https://spheres.dost.gov.ph/profiles/399-lourdes-j-cruz

STEM Women Global Network. (n.d.). Lourdes J Cruz. https://stemwomen.global/profile/lourdes-j-cruz

Swenson, H. (2022, September 16). Tiny Snail, Big Impact: Cone Snail Venom Eases Pain and Injects New Energy into Neuroscience — The Golden Goose Award. The Golden Goose Award. https://www.goldengooseaward.org/01awardees/snails